Background: There is a long controversial history between schizophrenia and autism. Suspect Molecules Overlap in Autism, Schizophrenia and Bipolar Disorder. “The results advance understanding of how risk factors across many genes contribute to the development of various mental disorders, in combination with environmental factors,” explained Geetha Senthil, Ph.D., of the NIMH Office of Genomics Research Coordination. Daniel Geschwind and Michael Gandal of the University of California Los Angeles (UCLA), and colleagues, examined gene expression in postmortem brains of people who had been diagnosed with autism spectrum disorder (ASD), schizophrenia, bipolar disorder, major depressive disorder, or alcoholism. and overlapping features between autism spectrum disorder and schizophrenia. Traci Pedersen is a professional writer with over a decade of experience. Psychiatry Res. Autism and schizophrenia have often been linked in some form or another, from the early days of diagnosis to cutting-edge genetic studies. Research in Autism Spectrum Disorders , 4 : 709–17. "The strength of our study is the systematic head-to-head comparison of pathogenic CNVs and biological pathways between autism spectrum disorder and schizophrenia," says senior author Norio Ozaki from Nagoya University Graduate School of Medicine. The enrichment of autism and intellectual disability among genes with de novo mutations was significant in repeated simulations controlling for gene size and GC content. Introduction. Schizophrenia, Autism and Overlap. Overall, early onset schizophrenia, although rare, is possible and often mistook for autism. Gong JB, Wang Y, Lui SSY, Cheung EFC, Chan RCK. The fuck up just gets delayed – it’s latent, which is why it happens in one’s teens/early 20s rather than toddlerhood. Autism spectrum disorders (ASDs) such as autism, Asperger’s syndrome and Rett’s syndrome, are develop-mental psychiatric disorders with high heritability [15]. Substantial overlap exists between schizophrenia and autism spectrum disorders, with part of that overlap hypothesised to be due to comorbid social anxiety. Over the past few years, genetic studies of ASDs have Review Genetic overlap between autism, schizophrenia and bipolar disorder Liam S Carroll and Michael J Owen Earlier researches have also found an existing link between genetic variants that are supposedly implicated in ASD, seizure disorder, schizophrenia and intellectual disability. The research is consistent with a complex relationship between autism and schizophrenia, consistent with both overlapping and exclusive relationships in psychology, behavior and etiology. The findings confirm a link between autism and schizophrenia with three of the eight subgroups revealing a combination of social and communication difficulties that are … The National Institute of Mental Health (NIMH) is part of the National Institutes of Health (NIH), a component of the U.S. Department of Health and Human Services. For example, schizophrenia (SCZ) and bipolar disorder (BD) showed the most such gene expression overlap, followed by autism spectrum disorder (ASD) and schizophrenia (SCZ). These findings suggest that schizophrenia, autism and other neurodevelopmental disorders may share underlying pathogenic mechanisms and challenges the view that these are … Genetic overlap between autism, schizophrenia and bipolar disorder @article{Carroll2009GeneticOB, title={Genetic overlap between autism, schizophrenia and bipolar disorder}, author={L. Carroll and M. Owen}, journal={Genome Medicine}, year={2009}, volume={1}, pages={102 - 102} } Authors: Michael Fitzgerald. Research Conducted at NIMH (Intramural Research Program), share many of the same genetic risk factors, NIMH Office of Genomics Research Coordination, Autism, schizophrenia, bipolar disorder share molecular traits, study finds, Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap, U.S. Department of Health and Human Services. In children with a deletion on chromosome 22, having autism does not boost the risk of developing schizophrenia later in life, according to a new study1.. JohnnyHG writes: There is evidence schizophrenia is developmental like Autism. Autism and schizophrenia are related. Recent studies suggest there are deeper relations in biological and clinical links between schizophrenia and autism. Significantly more schizotypal traits in adolescents with ASD were found than in typically developing controls. If there is some overlap or a relationship between the traits of autism-spectrum and schizophrenia-spectrum, then there should be a correlation between the AQ and SPQ the total scores. Abu-Akel A, Philip RCM, Lawrie SM, Johnstone EC, Stanfield AC. Although later diagnosing methods established a clear difference between autism and schizophrenia, genetic studies have established a link between … While the symptoms may overlap, they are considered two separate disorders in the DSM-5. Adding a Dimension to the Dichotomy: Affective Processes Are Implicated in the Relationship Between Autistic and Schizotypal Traits. Please enable it to take advantage of the complete set of features! Methods: Literature review. Similar patterns of overlap have been found among risk genes for the disorders. Schizotypal symptomatology in all sub dimensions that are reflected by the SPQ scores, was most prominently associated with attention switching problems of the autism symptoms from the AQ. Sporn , AL , Addington , AM , Gogtay , N et al ( 2004 ) Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness? Autism and Schizophrenia, though separate diagnostic entities, share some common clinical features. Whole-genome studies of many thousands of affected individuals are uncovering evidence for genetic overlap between autism, schizophrenia and bipolar disorder. The question regarding whether there is phenotypic overlap or comorbidity between autism and schizophrenia dates back to 1943, when Kanner 1 first used the term “autism” to describe egocentricity. Citing an estimate that a quarter of children with early-onset schizophrenia may have some type of “pervasive developmental disorder” (now lumped in with autism spectrum disorder), these researchers point out that careful evaluation is needed to suss out overlapping symptoms symptoms of possible autism and schizophrenia in children. Genetic overlap between autism, schizophrenia and bipolar disorder Genome Med. Larson FV, Wagner AP, Chisholm K, Reniers RLEP, Wood SJ. Epub 2019 Dec 13. The … The overlap between autistic and schizotypal features evidenced in PC1 is consistent with the high degree of conceptual, diagnostic, and phenotypic overlap observed between the broader social phenotypes of autism and schizophrenia, especially between Asperger’s syndrome and schizoid personality in childhood and/or schizotypal personality disorder (SPD) , , . The phenotypic overlap between autism spectrum disorder (ASD) and schizophrenia is complex and dates back to Kanner in 1943. [Psychiatric issues of children and adults with autism spectrum disorders who remain undiagnosed]. This site needs JavaScript to work properly. 2019 Oct;212:6-14. doi: 10.1016/j.schres.2019.07.050. Purpose. Overlap in molecular signatures across certain mental disorders is reflected in correlations of gene expression between mental disorders. Romero-Garcia R, Seidlitz J, Whitaker KJ, Morgan SE, Fonagy P, Dolan RJ, Jones PB, Goodyer IM, Suckling J; NSPN Consortium, Vértes PE, Bullmore ET. – Considerable confusion surrounds the overlapping of autism and schizophrenia. Overlap between autism and schizophrenia: history and current status Overlap between autism and schizophrenia: history and current status Michael Fitzgerald 2013-12-20 00:00:00 Purpose – Considerable confusion surrounds the overlapping of autism and schizophrenia. 2013 Nov;22(11):683-92. doi: 10.1007/s00787-013-0409-7. Until the late 1970s, autistic children commonly were wrongly diagnosed as having childhood schizophrenia. A group of 27 adolescents with ASD (11 to 18 years) and 30 typically developing adolescents, matched for age and gender, participated in this study. Recent studies comparing isolated symptoms of both spectrum disorders as well as diagnostic criteria for each (DSM-IV-TR) suggest resemblances in the clinical phenotype. The Attenuated Psychosis Syndrome and Facial Affect Processing in Adolescents With and Without Autism.  |  DOI: 10.1186/gm102 Corpus ID: 16959617. This has significant implications for clinicians given that correct diagnosis is critical for treatment. PMID:29439242, The National Institute of Mental Health Information Resource Center, Hours: 8:30 a.m. to 5 p.m. Eastern time, M-F, Phone:  1-866-615-6464 TTY:  1-301-443-8431 TTY (toll-free):  1-866-415-8051, Live Online Chat:  Talk to a representative Email:  nimhinfo@nih.gov Fax:  1-301-443-4279, Mail:  National Institute of Mental HealthOffice of Science Policy, Planning, and Communications6001 Executive Boulevard, Room 6200, MSC 9663Bethesda, MD 20892-9663. CarrollLS@cf.ac.uk. Revisiting the overlap between autistic and schizotypal traits in the non-clinical population using meta-analysis and network analysis. NIH The new study examined how different 16p11.2 and 22q11.2 CNVs alter the brain’s ‘ functional connectivity ,’ a measure of synchronous activity among brain regions. eCollection 2020. Spek, AA, Wouters, S (2010) Autism and schizophrenia in high functioning adults: behavioral differences and overlap. This implies that our current diagnostic classifications may be insufficient for individuals presenting with these characteristics. Schizophr Res. 2020 Aug 1;88(3):248-259. doi: 10.1016/j.biopsych.2019.12.005. Genes factoring in this enrichment were, CHD8, MECP2, AUTS2, HUWE1, and TRAPPC9. Front Psychiatry. It has also discovered that people in the general population can be categorised into eight subgroups depending on their autistic or schizophrenic traits. Epub 2017 Jul 17. Although later diagnosing methods established a clear difference between autism and schizophrenia, genetic studies have established a link between … Besides high levels of negative symptoms, adolescents with ASD also displayed high levels of positive and disorganized symptoms. In addition, the correlations between the AQ and SPQ subscale scores should identify which schizophrenic trait is related to autism-spectrum. Within the ASD group 11 adolescents satisfied DSM-IV-TR criteria for schizotypal personality disorders. Available evidence points to genetic overlap between the two clinically distinct disorders. With the ongoing consideration of the diagnostic criteria for mental disorders that is active in the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) and International Classification of Diseases (ICD-11) revision processes, it is timely to review the phenomenological overlap between autism and schizophrenia. USA.gov. Researchers have found overlap in mutations of genes in Schizophrenia and also those connected with mutations in autism and cognitive disabilities. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2013;115(6):601-6. Autism Spectrum Disorder (ASD) and Schizophrenia Spectrum Disorder (SSD): Current Understanding. (2)Department of Psychiatry and Behavioral … Until the late 1970s, autistic children commonly were wrongly diagnosed as having childhood schizophrenia. Researchers have long suspected that autism and schizophrenia are related.The two conditions have overlapping traits, including sensory-processing problems and social difficulties, and they share gene-expression patterns in brain tissue. Copyright © 2010 Elsevier B.V. All rights reserved. Recently, research demonstrated that autism and schizophrenia are genetically linked (Burbach & van der Zwaag, 2009).Apparently, the two disorders share common genotypical features, therefore phenotypical (cognitive) and endophenotypical (behavioral) overlap can be expected (Braff et al., 2007, Happé and Frith, 1996).In order to classify the two disorders correctly in … eCollection 2020. The question remained settled until the 1990s, when more sophisticated analyses reopened it. Pathways to psychosis: a comparison of the pervasive developmental disorder subtype Multiple Complex Developmental Disorder and the "At Risk Mental State". Although significant advancements in the process of differential diagnosis have been made since 1950s, there still exists a problematic delay in diagnosis due to overlap of symptoms. People with different psychiatric disorders such a autism, schizophrenia and bipolar disorder have different diagnoses but they share symptoms and may share common genetic roots. Source: Daniel Geschwind, M.D., Ph.D., UCLA. Overlap in molecular signatures across certain mental disorders is reflected in correlations of gene expression between mental disorders. In search of such clues, Drs. Spek, AA, Wouters, S (2010) Autism and schizophrenia in high functioning adults: behavioral differences and overlap. Recently, research demonstrated that autism and schizophrenia are genetically linked (Burbach & van der Zwaag, 2009).Apparently, the two disorders share common genotypical features, therefore phenotypical (cognitive) and endophenotypical (behavioral) overlap can be expected (Braff et al., 2007, Happé and Frith, 1996).In order to classify the two disorders correctly in … Sprong M, Becker HE, Schothorst PF, Swaab H, Ziermans TB, Dingemans PM, Linszen D, van Engeland H. Schizophr Res. Traci Pedersen is a professional writer with over a decade of experience. There is strong evidence that genetic factors make substantial contributions to the etiology of autism, schizophrenia and bipolar disorders, with heritability estimates being at least 80% for each. Front Psychiatry. The childhood schizophrenia is a diagnostic category that has led to numerous controversies by its overlap with other categories, such as infantile autism. Autism and schizophrenia have often been linked in some form or another, from the early days of diagnosis to cutting-edge genetic studies. Results: The overlap phenomology genetics will be Aim: To detail the history of the relationship between autism and schizophrenia. Schizophrenia and Autism: Similarities and Differences . How many are seen as being both ASD and schizotypal ? Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP; CommonMind Consortium; PsychENCODE Consortium; iPSYCH-BROAD Working Group, Horvath S, Geschwind DH. July 2012; Neuropsychiatrie de l Enfance et de l Adolescence IX(4):171-6; DOI: 10.1016/j.neurenf.2012.04.060. Psychiatric Co-morbidities in ASD: A Focus on Schizophrenia Study of over 1 million people discusses overlap of ASD and schizophrenia . Schizotypy-Related Magnetization of Cortex in Healthy Adolescence Is Colocated With Expression of Schizophrenia-Related Genes. According to that edition of the DSM, there was no overlap: Autism and schizophrenia could not co-occur. Reply Cancel Cancel; Parents. This study addresses the unraveling of the relationship between autism spectrum and schizophrenia spectrum traits in a population of adolescents with Autism Spectrum Disorders (ASD). COVID-19 is an emerging, rapidly evolving situation. The purpose of this study was to specify overlapping symptom domains and to identify symptoms that can reliably differentiate adults with ASD (n = 53), SZ (n = 39), and typical development (TD; n = 40). ISSN: 2044-1282. In addition, some family and … HHS To investigate this connection, we examined the relationship between autistic traits and obsessive-compulsive traits. Schizophrenia is rare among children, and some of the symptoms and risk factors may overlap with those of autism. Overlap in molecular signatures across certain mental disorders is reflected in correlations of gene expression between mental disorders. Biol Psychiatry. These findings indicate that patients diagnosed with an ASD show schizophrenia spectrum traits in adolescence. The difference in opinion between the two continued to remain unclear for more than three decades until the DSM-II was involved. The question regarding whether there is phenotypic overlap or comorbidity between autism and schizophrenia dates back to 1943, when Kanner 1 first used the term “autism” to describe egocentricity. Traci Pedersen. Data on 14 males with autism and 14 with schizophrenia were collected to examine symptom overlap. Exploring the commonalities between autism spectrum disorder and schizophrenia could provide new insight to MH106438, MH094714, MH103339, MH110927, MH100027,
 MH110920, MH103340, MH103365, MH103392, MH103340, MH103346, MH105472, MH094714, MH105898, MH102791, MH105881, MH103877, MH106934, RMH085542, MH093725, MH066392, MH080405, MH097276, MH-075916, M096891, MH084053S1, MH057881, MH057881S1, AG02219, AG05138, MH06692, UCLA news release: Autism, schizophrenia, bipolar disorder share molecular traits, study finds, Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Autism spectrum disorder (ASD) and schizophrenia (SZ) are heterogenous neurodevelopmental disorders that overlap in symptom presentation. By: Leigh Hopper UCLA Health/David Geffen School of Medicine; April 1st, 2018; autism, behavior, genetics, health, mental health, research, spring 2018 issue; 307 0 There appeared to be a relationship between the mean level of autistic symptoms and schizotypal traits, as well as specific associations between autistic symptoms and negative, disorganized and positive schizotypal symptoms within individuals. Traci Pedersen. Autistic and schizotypal traits were identified by means of well validated questionnaires (Autism Questionnaire, AQ and Schizotypal Personality Questionnaire-Revised, SPQ). Studies of CNVs and other rare alleles have found overlap between autism and schizophrenia, whereas those of common SNP variants have shown overlap between schizophrenia and bipolar disorder. 2008 Feb;99(1-3):38-47. doi: 10.1016/j.schres.2007.10.031. You can read the article here. In the past two decades, a growing number of studies have produced a wealth of complex, sometimes contradictory, evidence. When a child is being evaluated by a psychologist, most often their early onset schizophrenia can be misdiagnosed as autism spectrum disorder, due to their overlap in social dysfunction symptoms (University of Texas at Dallas, 2012). How many have gone in for an ASD assessment to be told they are schizotypal? Overlap between autism and schizophrenia: history and current status. Recent studies suggest there are deeper relations in biological and clinical links between schizophrenia and autism. 2020 Jul 24;11:712. doi: 10.3389/fpsyt.2020.00712. Emerging study results suggest that there are both clinical and biological links between autism and schizophrenia. The Structured Clinical Interview (SCID), the schedule for positive symptoms (SAPS) and the schedule for negative symptoms (SANS) of schizophrenia, the Childhood Autism Rating Scale (CARS), and the DSM-III-R were administered. Posted Jun 10, 2019 For example, schizophrenia (SCZ) and bipolar disorder (BD) showed the most such gene expression overlap, followed by autism spectrum disorder (ASD) and schizophrenia (SCZ). In children with a deletion on chromosome 22, having autism does not boost the risk of developing schizophrenia later in life, according to a new study1.. Fagel SS, Swaab H, De Sonneville LM, Van Rijn S, Pieterse JK, Scheepers F, Van Engeland H. Eur Child Adolesc Psychiatry. Epub 2007 Dec 4. By: Leigh Hopper UCLA Health/David Geffen School of Medicine; April 1st, 2018; autism, behavior, genetics, health, mental health, research, spring 2018 issue; 307 0; Most medical disorders have well-defined physical characteristics seen in tissues, organs and bodily fluids. Robert123 over 3 years ago. 2018 Feb 9;359(6376):693-697. doi: 10.1126/science.aad6469. Autism Spectrum Disorder (ASD) and Schizophrenia Spectrum Disorder (SSD): Current Understanding. NLM Zhou HY, Yang HX, Gong JB, Cheung EFC, Gooding DC, Park S, Chan RCK.  |  Significant Genetic Overlap Found Between Schizophrenia, Autism. Science. New research at Swinburne has revealed a significant overlap in the traits associated with autism and schizophrenia. GeneAnalytics Pathway Analysis and Genetic Overlap among Autism Spectrum Disorder, Bipolar Disorder and Schizophrenia. Recent studies comparing isolated symptoms of both spectrum disorders as well as diagnostic criteria for each (DSM-IV … Posted on February 21, 2014 by jm2walsh. Autism is more often linked to 16p11.2 deletions and 22q11.2 duplications, whereas schizophrenia is more often associated with 16p11.2 duplications and 22q11.2 deletions. Now, researchers have discovered that this overlap extends to the molecular level – some of these suspect genes also turn on-and-off similarly in the brains of people with autism spectrum disorder (ASD), schizophrenia, and bipolar disorder. , – This paper sets out to clarify the position by reviewing the history and current status of the relationship between autism and schizophrenia. Stanfield , AC , Philip , RCM , Whalley , H , Romaniuk , L , Hall , J , Johnstone , EC et al. In addition to the overlap between ASD and schizophrenia or the overlap between autism-spectrum and schizophrenic traits, we are also interested in the connection between ASD and OCD. Spek, AA and Wouters, SGM (2010) Autism and schizophrenia in high functioning adults: behavioral differences and overlap. This study addresses the unraveling of the relationship between autism spectrum and schizophrenia spectrum traits in a population of adolescents with Autism Spectrum Disorders (ASD). Starting with the DSM-III, ASD and schizophrenia …  |  I would exclude the cases of diagnosis of someone with a history of drug use or brief psychotic hallucinations from environment. Clipboard, Search History, and several other advanced features are temporarily unavailable. Suspect Molecules Overlap in Autism, Schizophrenia and Bipolar Disorder. Development of schizotypal symptoms following psychiatric disorders in childhood or adolescence. Although other studies have provided empirical support for this overlap in diagnostic criteria between both spectrum disorders, the present findings add to the literature that behavioral overlap is not limited to negative schizotypal symptoms, but extends to disorganized and positive symptoms as well. Autism and Schizophrenia: behavioral differences and overlap Annelies Spek GGZ Eindhoven - View full program and videos on www.autismeurope2010.org Krug A, Wöhr M, Seffer D, Rippberger H, Sungur AÖ, Dietsche B, Stein F, Sivalingam S, Forstner AJ, Witt SH, Dukal H, Streit F, Maaser A, Heilmann-Heimbach S, Andlauer TFM, Herms S, Hoffmann P, Rietschel M, Nöthen MM, Lackinger M, Schratt G, Koch M, Schwarting RKW, Kircher T. Mol Autism. For example, schizophrenia (SCZ) and bipolar disorder (BD) showed the most such gene expression overlap, followed by autism spectrum disorder (ASD) and schizophrenia (SCZ). Introduction. This provides support for a specific overlap between schizophrenia and autism at the gene level. Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study. 1. Main Digest Researchers Confirm Genetic Link between Autism and Schizophrenia. Related Articles. Khanzada NS(1), Butler MG(2)(3), Manzardo AM(4). Childhood trauma is not a confounder of the overlap between autistic and schizotypal traits: A study in a non-clinical adult sample. Affiliation 1 MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK. Considerable confusion surrounds the overlapping of autism and schizophrenia. nkhanzada@kumc.edu. Evidence has been mounting that some mental disorders share many of the same genetic risk factors. Related Articles. Get the latest public health information from CDC: https://www.coronavirus.govGet the latest research information from NIH: https://www.nih.gov/coronavirusGet the latest shareable resources on coping with COVID-19 from NIMH: https://www.nimh.nih.gov/covid19, Jules Asher NIMH Press Office 301-443-4536 NIMHpress@nih.gov, Shared patterns of gene expression may hold clues to disease processes. Epub 2019 Aug 3. One of the largest such efforts of its kind to date, the study, funded by the National Institute of Mental Health (NIMH), tapped brain molecular data resources gathered through the NIMH-funded PsychENCODE consortium, a data-sharing collaboration among NIMH grantees. eCollection 2020. Categorical and Dimensional Approaches to Examining the Joint Effect of Autism and Schizotypal Personality Disorder on Sustained Attention. Michael Fitzgerald (Professor of Child Psychiatry, based at Department of Psychiatry, Trinity College, Dublin, UK) Advances in Mental Health and Intellectual Disabilities. For example, the researchers found that synapse and neuro-immune functions were similarly impacted in autism, schizophrenia, and bipolar disorder. I was excited, three weeks ago, to read information about some new studies being conducted in the field of genetics. “The study also highlights the importance of such large-scale team science efforts in gaining insights into the biology underlying mental disorders.”. Get the latest public health information from CDC: https://www.coronavirus.gov. This has significant implications for clinicians given that correct diagnosis is critical for treatment. Studies of CNVs and other rare alleles have found overlap between autism and schizophrenia, whereas those of common SNP variants have shown overlap between schizophrenia and bipolar disorder. Nevertheless, the question of overlap between the two dates back to as early as 1943. Publication date: 1 January 2014 . 2020 Aug 7;11:798. doi: 10.3389/fpsyt.2020.00798. A recent case study and review highlight overlap between ASD and PTSD. 2020 Jun 23;11(1):54. doi: 10.1186/s13229-020-00345-2. The developmental disorders include communication deficiency, motor development delays and social difficulties that have a similarity to those seen in autism-related disorders. Schizophrenia and Autism Overlap and Difference. 2020 Aug 3;11:759. doi: 10.3389/fpsyt.2020.00759. 1 Individuals affected by … I am wondering what people think about the overlap and differences between ASD and schizotypal. Nowadays it is still not included in any diagnostic and classification manual of mental illnesses (DSM or CIE), however, cases of children with psychotic symptoms in childhood and the beginning of adolescence are known. Kamio Y, Moriwaki A, Takei R, Inada N, Inokuchi E, Takahashi H, Nakahachi T. Seishin Shinkeigaku Zasshi. Epub 2013 Apr 7. Authors Liam S Carroll 1 , Michael J Owen. Author information: (1)Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center, Kansas City, KS 66160, USA. As reported February 9, 2018, in Science, the study demonstrated – for the first time – that disorders with a large overlap in genetic risk factors also had a large overlap in patterns of gene expression and shared dysfunction in similar molecular pathways.
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